The role of exercise in atrial fibrillation prevention and promotion: Finding optimal ranges for health

The cardiovascular benefits of regular exercise have been well described, including a significant reduction in cardiovascular morbidity and mortality for those meeting recommended guidelines. Yet the impact of physical activity on the incidence of atrial fibrillation (AF) has been less clear. This review seeks to define the optimal dose and duration for the prevention and treatment of AF. In doing so, we review the evidence that supports a decline in AF risk for those who achieve a weekly physical activity dose slightly above the current recommended guidelines. Furthermore, we identify the reduced AF incidence in those individuals who attain a cardiorespiratory fitness of 8 METs (metabolic equivalents of task) or more during maximal exercise testing. Finally, we review the evidence that shows an excess of AF among regular participants of endurance exercise

Red material on the large moons of Uranus: Dust from irregular satellites?

The large and tidally-locked classical moons of Uranus display longitudinal and planetocentric trends in their surface compositions. Spectrally red material has been detected primarily on the leading hemispheres of the outer moons, Titania and Oberon. Furthermore, detected H2O ice bands are stronger on the leading hemispheres of the classical satellites, and the leading/trailing asymmetry in H2O ice band strengths decreases with distance from Uranus. We hypothesize that the observed distribution of red material and trends in H2O ice band strengths results from infalling dust from Uranian irregular satellites. These dust particles migrate inward on slowly decaying orbits, eventually reaching the classical satellite zone, where they collide primarily with the outer moons. The latitudinal distribution of dust swept up by these moons should be fairly even across their southern and northern hemispheres. However, red material has only been detected over the southern hemispheres of these moons (subsolar latitude 81 S). Consequently, to test whether irregular satellite dust impacts drive the observed enhancement in reddening, we have gathered new ground-based data of the now observable northern hemispheres of these moons (sub-observer latitudes, 17 to 35 N). Our results and analyses indicate that longitudinal and planetocentric trends in reddening and H2O ice band strengths are broadly consistent across both southern and northern latitudes of these moons, thereby supporting our hypothesis. Utilizing a suite of numerical best fit models, we investigate the composition of the reddening agent detected on these moons, finding that both complex organics and amorphous pyroxene match the spectral slopes of our data. We also present spectra that span 2.9 to 4.1 microns, a previously unexplored wavelength range in terms of spectroscopy for the Uranian moons.Comment: Icarus [In Press]. 12 figures, 15 table

High‐efficiency Al0.22Ga0.78As solar cells grown by molecular beam epitaxy

The quality of pn junction photodetectors made of Al0.2Ga0.8As has been investigated as a first step in the optimization of tandem solar cells. We have obtained 1 sun AM1.5 efficiencies of 16.1% for 0.25 cm2 Al0.22Ga0.78As solar cellsfabricated from molecular beam epitaxy (MBE) material. This efficiency is 3.2 percentage points higher than the previously best reported efficiency of 12.9% for an Al0.2Ga0.8As solar cell fabricated from MBE material

Closed-loop acoustic stimulation during sedation with dexmedetomidine (CLASS-D): Protocol for a within-subject, crossover, controlled, interventional trial with healthy volunteers

Introduction: The relative power of slow-delta oscillations in the electroencephalogram (EEG), termed slow-wave activity (SWA), correlates with level of unconsciousness. Acoustic enhancement of SWA has been reported for sleep states, but it remains unknown if pharmacologically induced SWA can be enhanced using sound. Dexmedetomidine is a sedative whose EEG oscillations resemble those of natural sleep. This pilot study was designed to investigate whether SWA can be enhanced using closed-loop acoustic stimulation during sedation (CLASS) with dexmedetomidine. Methods: Closed-Loop Acoustic Stimulation during Sedation with Dexmedetomidine (CLASS-D) is a within-subject, crossover, controlled, interventional trial with healthy volunteers. Each participant will be sedated with a dexmedetomidine target-controlled infusion (TCI). Participants will undergo three CLASS conditions in a multiple crossover design: in-phase (phase-locked to slow-wave upslopes), anti-phase (phase-locked to slow-wave downslopes) and sham (silence). High-density EEG recordings will assess the effects of CLASS across the scalp. A volitional behavioral task and sequential thermal arousals will assess the anesthetic effects of CLASS. Ambulatory sleep studies will be performed on nights immediately preceding and following the sedation session. EEG effects of CLASS will be assessed using linear mixed-effects models. The impacts of CLASS on behavior and arousal thresholds will be assessed using logistic regression modeling. Parametric modeling will determine differences in sleepiness and measures of sleep homeostasis before and after sedation. Results: The primary outcome of this pilot study is the effect of CLASS on EEG slow waves. Secondary outcomes include the effects of CLASS on the following: performance of a volitional task, arousal thresholds, and subsequent sleep. Discussion: This investigation will elucidate 1) the potential of exogenous sensory stimulation to potentiate SWA during sedation; 2) the physiologic significance of this intervention; and 3) the connection between EEG slow-waves observed during sleep and sedation

Non-perturbative behavior of the quantum phase transition to a nematic Fermi fluid

We discuss shape (Pomeranchuk) instabilities of the Fermi surface of a two-dimensional Fermi system using bosonization. We consider in detail the quantum critical behavior of the transition of a two dimensional Fermi fluid to a nematic state which breaks spontaneously the rotational invariance of the Fermi liquid. We show that higher dimensional bosonization reproduces the quantum critical behavior expected from the Hertz-Millis analysis, and verify that this theory has dynamic critical exponent $z=3$. Going beyond this framework, we study the behavior of the fermion degrees of freedom directly, and show that at quantum criticality as well as in the the quantum nematic phase (except along a set of measure zero of symmetry-dictated directions) the quasi-particles of the normal Fermi liquid are generally wiped out. Instead, they exhibit short ranged spatial correlations that decay faster than any power-law, with the law $|x|^{-1} \exp(-\textrm{const.} |x|^{1/3})$ and we verify explicitely the vanishing of the fermion residue utilizing this expression. In contrast, the fermion auto-correlation function has the behavior $|t|^{-1} \exp(-{\rm const}. |t|^{-2/3})$. In this regime we also find that, at low frequency, the single-particle fermion density-of-states behaves as $N^*(\omega)=N^*(0)+ B \omega^{2/3} \log\omega +...$, where $N^*(0)$ is larger than the free Fermi value, N(0), and $B$ is a constant. These results confirm the non-Fermi liquid nature of both the quantum critical theory and of the nematic phase.Comment: 20 pages, 2 figures, 1 table; new version with minor changes; new subsection 3C2 added with an explicit calculation of the quasiparticle residue at the nematic transition; minor typos corrected, new references; general beautification of the text and figure

ExploreNEOs. III. Physical Characterization of 65 Potential Spacecraft Target Asteroids

Space missions to near-Earth objects (NEOs) are being planned at all major space agencies, and recently a manned mission to an NEO was announced as a NASA goal. Efforts to find and select suitable targets (plus backup targets) are severely hampered by our lack of knowledge of the physical properties of dynamically favorable NEOs. In particular, current mission scenarios tend to favor primitive low-albedo objects. For the vast majority of NEOs, the albedo is unknown. Here we report new constraints on the size and albedo of 65 NEOs with rendezvous Δv <7 km s^(–1). Our results are based on thermal-IR flux data obtained in the framework of our ongoing (2009-2011) ExploreNEOs survey using NASA's "Warm-Spitzer" space telescope. As of 2010 July 14, we have results for 293 objects in hand (including the 65 low-Δv NEOs presented here); before the end of 2011, we expect to have measured the size and albedo of ~700 NEOs (including probably ~160 low-Δv NEOs). While there are reasons to believe that primitive volatile-rich materials are universally low in albedo, the converse need not be true: the orbital evolution of some dark objects likely has caused them to lose their volatiles by coming too close to the Sun. For all our targets, we give the closest perihelion distance they are likely to have reached (using orbital integrations from Marchi et al. 2009) and corresponding upper limits on the past surface temperature. Low-Δv objects for which both albedo and thermal history may suggest a primitive composition include (162998) 2001 SK162, (68372) 2001 PM9, and (100085) 1992 UY4

Thermophysical Characterization of Potential Spacecraft Target (101955) 1999 RQ36

We report on thermal emission measurements of 1999 RQ36 from Spitzer. The derived size is in agreement with radar measurements, and we find a moderately high thermal inertia and homogeneous surface properties